My research mainly focuses to study the underlying mechanisms of mechano-transduction and autophagy in 2D/3D models for cell metabolisms including cell protrusion, adhesion and differentiation. I also work on developing stem-cells derived 3D organoid models of intestinal epithelium for the development of drug screening and translation medicine. Outside of lab, I enjoy ball games, hiking and organic farming.

Publications in recent years:

1.      Lam KL, et al., Rac1-GTPase regulates compression-induced mechanopodia of mesenchymal stem cells in 3D collagen micro-tissues, Biomaterials 2021 DOI: 10.1016/j.biomaterials.2021.120829 .

2.      Li, CW, Lau YT, Lam KL, et al. Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells, Biomaterials 2020 doi: 10.1016/j.biomaterials.2020.120292

3.      Li YY, Lam KL, et al. Collagen microencapsulation recapitulates mesenchymal condensation and potentiates chondrogenesis of human mesenchymal stem cells - A matrix-driven in vitro model of early skeletogenesis. Biomaterials 2019 doi: 10.1016/j.biomaterials.2019.05.021

4.      Diao HJ, Fung HS, Yeung P, Lam KL, et al. Dynamic cyclic compression modulates the chondrogenic phenotype in human chondrocytes from late stage osteoarthritis. Biochemical and biophysical research communications 2017 doi: 10.1016/j.bbrc.2017.02.073

5.      Lam KL, et al, Roles of actin cytoskeletal dynamics on cyclic compression-induced autophagy in 3D collagen encapsulated human mesenchymal stem cells (Paper in preparation).

6.      Li, CW, Lam KL, et al, Association of Rho-GTPases signalling pathways for the decellularized CDM-induced active spike formation in human mesenchymal cells (Paper in preparation).

7.      Li, CW, Lam KL, et al, Study of fibronectin-stimulated maturation of 3D matix adhersion in MSC collagen micro-tissues, (Paper in preparation).