Biomimetic Scaffolds
Biomimetic scaffolds mimic important features of the extracellular matrix (ECM) and can be finely controlled at the nano- or microscale. Rational design of biomimetic scaffolds is based on consideration of the ECM as a natural scaffold; ECM provides a niche for cell adhesion, migration, proliferation, and differentiation. We are working on fabrication of different biomimetic scaffolds that recapitulating the composition, structure, and function of the native tissues. For example, we are developing a collagen microspheres-based scaffold for mimicking the ear cartilage; and a glycosaminoglycans (GAGs)-rich scaffold to mimic the ECM of the nucleus nucleus pulposus and cartilage. These biomimetic scaffolds can be used for tissue regeneration.