Microencapsulation
Microencapsulation is the process to entrap cells within the confines of a semi-permeable membrane or a homogenous solid matrix. We have developed a microencapsulation technology to entrap cells within a dense meshwork of extracellular matrix (ECM) components, such as nano-sized collagen fibers, laminin, fibronectin, and glycosaminoglycans (GAGs). This meshwork is able to support growth and proliferation, migration, and differentiation of cells. Many cell types including mesenchymal stem cells, embryonic stem cells, chondrocytes and fibroblasts have been successfully encapsulated. The microspheres are being developed for tissue engineering applications. We are also developing biomimetic and functional materials for use in various tissue engineering applications.