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Selected Publications

Prof. Yuan Lin

Dr. Lin joined the University of Hong Kong in 2008 and is now a Professor in Department of Mechanical Engineering.

Dr. Lin obtained a MS degree in Applied Mathematics from Brown University in 2004, followed by a Ph.D degree in Solid Mechanics in 2008.

Dr. Lin received the BS and MS degrees in Engineering Mechanics from Tsinghua University in 2000 and 2001, respectively.

Selected Publications

2024

J. Jing, F. Sun, Z. Wang, L. Ma, Y. Luo, Z. Du, T. Zhang, Y. Wang, F. Xu, X. Ma, Y. He, H. Sun, X. Wang, Y. Zhou, J.K.H. Tsoi, J. Wrachtrup, N. Wong, C. Li, D.-K. Ki, Q. Wang, K.H. Li, Y. Lin* and Z. Chu*. 2024. Scalable production of ultraflat and ultraflexible diamond membrane. Nature . 636: 627-634.

Q. Cui, Y. Tian, Z. Wu, L. Zhang, W.C. Cho, S. Yao and Y. Lin*. 2024. Concurrently Probing the Mechanical and Electrical Characteristics of Living Cells via an Integrated Microdevice. Nano Letters. 24: 14522-14530.

J. Xing, F. Sun, Y. Lin* and Z. Gong*. 2024. A Chemo-Mechanical Model for Growth and Mechanosensing of Focal Adhesion. Journal of the Mechanics and Physics of Solids . 193: 105863.

W. Huang, Z. Wang, D.W.Y. Au, B. Tang, B. Qi, W.C. Cho and Y. Lin*. 2024. Rapid and automatic phenotyping of cells through their annexin-mediated enforced blebbing response. AIP Advances. 14: 035344.

T. Zhang, F. Sun, Y. Wang, Y. Li, J. Wang, Z. Wang, K.H. Li, Y. Zhu, Q. Wang, L. Shao, N. Wong, D. Lei, Y. Lin* and Z. Chu*. 2024. Scalable Reshaping of Diamond Particles via Programmable Nanosculpting. ACS Nano. In Press.

W. Xie, L. Ma, P. Wang, X. Liu, D. Wu, Y. Lin, Z. Chu, Y. Hou and Q. Wei. 2024. Dynamic Regulation of Cell Mechanotransduction through Sequentially Controlled Mobile Surfaces. Nano Letters . 24: 7953-7961.

2023

F. Sun, C. Fang, X. Shao, H. Gao and Y. Lin*. 2023. A Mechanism-Based Theory of Cellular and Tissue Plasticity. Proceedings of the National Academy of Sciences USA. 120: e2305375120.

X. Shao, Y. Zhang and Y. Lin*. 2023. Cyclic stretch-regulated wound healing. Biophysical Journal. 122: P2381-2382.

M. Sun, H. Li, Y. Hou, N. Huang, X. Xia, H. Zhu, Q. Xu, Y. Lin and L. Xu. 2023. Multifunctional Tendon-Mimetic Hydrogels. Science Advances. 9: eade6973.

B.-C. Wang, Y. Lin and G.-K. Xu. 2023. Size-induced motion mode transitions in collective cell invasion toward free spaces. Soft Matter . 19: 4526-4535.

C. Fang, X. Shao, Y. Tian, Z. Chu and Y. Lin*. 2023. Size-dependent Response of Cells in Epithelial Tissue Modulated by Contractile Stress Fibers. Biophysical Journal. 122: 1315-1324.

W. Xie, X. Wei, H. Kang, H. Jiang, Z. Chu, Y. Lin, Y. Hou and Q. Wei. 2023. Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction. Advanced Science. 2204594.

2022

H. He, X. Wei, B. Yang, H. Liu, M. Sun, Y. Li, A. Yan, C. Tang, Y. Lin* and L. Xu*. 2022. Ultrastrong and Multifunctional Aerogels with Hyperconnective Network of Composite Polymeric Nanofibers. Nature Communications. 13: 4242.

C. Fang, J. Yao, Y. Zhang and Y. Lin*. 2022. Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces. Biophysical Journal. 121: 1266-1275.

D. Wu, Y. Hou, Z. Chu, Q. Wei, W. Hong and Y. Lin*. 2022. Ligand Mobility-Mediated Cell Adhesion and Spreading. ACS Applied Materials & Interfaces. 14: 12976-12983.

L. Wang, Y. Hou, T. Zhang, X. Wei, Y. Zhou, D. Lei, Q. Wei, Y. Lin* and Z. Chu*. 2022. All-Optical Modulation of Single Defects in Nanodiamonds: Revealing Rotational and Translational Motions in Cell Traction Force Fields. Nano Letters. 22: 7714-7723.

Z. Yan, X. Xia, W.C. Cho, D.W. Au, X. Shao, C. Fang, Y. Tian and Y. Lin*. 2022. Rapid Plastic Deformation of Cancer Cells Correlates with High Metastatic Potential. Advanced Healthcare Materials. 11: 2101657.

Y. Hou, J. Jing, Y. Luo, F. Xu, W. Xie, L. Ma, X. Xia, Q. Wei, Y. Lin,* K.H. Li* and Z. Chu*. 2022. A Versatile, Incubator-Compatible, Monolithic GaN PhotonicChipscope for Label-Free Monitoring of Live Cell Activities. Advanced Science. 9: 2200910.

H. Liu, H. Li, Z. Wang, X. Wei, H. Zhu, M. Sun, Y. Lin and L. Xu. 2022. Robust and Multifunctional Kirigami Electronics with Tough and Permeable Aramid Nanofiber Framework. Advanced Materials. 2207350.

J. Oh, X. Xia, W.K.R. Wong, S.H.D. Wong, W. Yuan, H. Wang, C.H.N. Lai, Y. Tian, Y.-P. Ho, H. Zhang, Y. Zhang, G. Li, Y. Lin* and L. Bian*. 2022. The Effect of the Nanoparticle Shape on T Cell Activation. Small. 18: 2107373.

2021

C. Fang, X. Wei, X. Shao and Y. Lin*. 2021. Force-mediated Cellular Anisotropy and Plasticity Dictate the Elongation Dynamics of Embryos. Science Advances. 7: eabg3264.

X. Wei, C. Fang, B. Gong, X. Shao, F. Sun, J. Qian and Y. Lin*. 2021. Time-dependent response of bio-polymer networks regulated by catch and slip bond-like kinetics of cross-linkers. Journal of the Mechanics and Physics of Solids. 147: 104267.

W. Yuan, H. Wang, C. Fang, Y. Yang, X. Xia, B. Yang, Y. Lin*, G Li* and L. Bian*. 2021. Microscopic local stiffening in supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration. Materials Horizons. 8: 1722-1734.

X. Wei, C. Fang, B. Gong, J. Yao, J. Qian and Y. Lin*. 2021. Viscoelasticity of 3D actin networks dictated by the mechanochemical characteristics of cross-linkers. Soft Matter. 17: 10177-10185.

X. Shao, M.H. Sorensen, C. Fang, R.C.C. Chang, Z. Chu and Y. Lin*. 2021. Maturation of neural cells leads to enhanced axon-extracellular matrix adhesion and altered injury response. Frontiers in Bioengineering and Biotechnology. 8: 621777.

T. Zhang, L. Ma, L. Wang, F. Xu, Q. Wei, W. Wang, Y. Lin and Z Chu. 2021. Scalable Fabrication of Clean Nanodiamonds via Salt-Assisted Air Oxidation: Implications for Sensing and Imaging. ACS Applied Nano Materials. 4: 9223-9230.

2020

H. Liu, C. Fang, Z. Gong, R.C.C. Chang, J. Qian, H. Gao and Y. Lin*. 2020. Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing. Biophysical Journal. 118: 1811-1819.

C. Fang, F. Zheng, J. Yao, X. Wei, C. Fu, X. Shi and Y. Lin*. 2020. A Model for Bridging Microtubule Dynamics with Nuclear Envelope Shape Evolution during Closed Mitosis. Journal of the Mechanics and Physics of Solids. 144: 104116.

H. Lee, Z. Gan, M. Chen, S. Min, J. Yang, Z. Xu, X. Shao, Y. Lin, W.-D. Li and J.T. Kim. 2020. On-Demand 3D Printing of Nanowire Probes for High-Aspect-Ratio Atomic Force Microscopy Imaging. ACS Applied Materials & Interfaces. 12: 46571–46577.

X. Shao, M.H. Sorensen, X. Xia, C. Fang, T.H. Hui, R.C.C. Chang, Z. Chu and Y. Lin*. 2020. Beading of injured axons driven by tension- and adhesion-regulated membrane shape instability. Journal of the Royal Society Interface. 17: 20200331.

Z. Gong, C. Fang, R. You, X. Shao, R.C.C. Chang and Y. Lin*. 2020. Forced peeling and relaxation of neurite governed by rate-dependent adhesion and cellular viscoelasticity. Extreme Mechanics Letters. 40: 100902.

Y. Zhang, Z. Yan, X. Xia, and Y. Lin*. 2020. A Novel Electroporation System for Living Cell Staining and Membrane Dynamics Interrogation. Micromachines. 111: 767.

2019

X. Shao, R. You, T.H. Hui, C. Fang, Z. Gong, Z. Yan, R.C.C. Chang, V.B. Shenoy and Y. Lin*. 2019. Tension- and Adhesion-Regulated Retraction of Injured Axons. Biophysical Journal. 117: 193-202.

B. Gong, J. Lin, X. Wei, J. Qian and Y. Lin*. 2019. Cross-linked biopolymer networks with active motors: Mechanical response and intra-network transport. Journal of the Mechanics and Physics of Solids. 127: 80-93.

T.H. Hui, W.C. Cho, H.W. Fong, M. Yu, K.W. Kwan, K.C. Ngan, K.H. Wong, Y. Tan, S. Yao, H. Jiang, Z. Gu and Y. Lin*. 2019. An electro-osmotic microfluidic system to characterize cancer cell migration under confinement. Journal of the Royal Society Interface. 16: 20190062.

B. Gong, X. Wei, J. Qian and Y. Lin*. 2019. Modeling and Simulations of the Dynamic Behaviors of Actin-Based Cytoskeletal Networks. ACS Biomaterials Science & Engineering. 5: 3720-3734.

Z. Gong, C. Fang, R. You, X. Shao, X. Wei, R.C.C. Chang and Y. Lin*. 2019. Distinct Relaxation Timescales of Neurites Revealed by Rate-dependent Indentation, Relaxation and Micro-rheology Tests. Soft Matter. 15: 166-174 (Journal cover article).

2018

Z. Gong, S.E. Szczesny, S.R. Caliari, E.E. Charrier, O. Chaudhuri, X. Cao, Y. Lin*, R.L. Mauck, P.A. Janmey, J.A. Burdick and V.B. Shenoy*. 2018. Matching Material and Cellular Timescales Maximizes Cell Spreading on Viscoelastic Substrates. Proceedings of the National Academy of Sciences USA. 115: E2686-E2695.

T.H. Hui, Y.H. Tang, Z. Yan, T.C. Yip, H.W. Fong, W.C. Cho, K.C. Ngan, H.C. Shum and Y. Lin*. 2018. Cadherin- and Rigidity-Dependent Growth of Lung Cancer Cells in a Partially Confined Microenvironment. ACS Biomaterials Science & Engineering. 4: 446-455.

T.H. Hui, X. Wei and Y. Lin*. 2018. Interrogating the Electromechanical Regulation of Cellular Volume at the Single-Cell Level. Biophysical Journal. 114: 2030-2031.

Z. Yan, T.H. Hui, H.W. Fong, X. Shao, W.C. Cho, K.C. Ngan, T.C. Yip and Y. Lin*. 2018. An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells. Biomedical Physics & Engineering Express. 4: 027001.

C. Fang, T.H. Hui, X. Wei, Z. Yan, J. Qian and Y. Lin*. 2018. Interaction and fusion dynamics between cellular blebs. Journal of Biomechanics. 81: 113-121.

2017

X. Cao, E. Ban, B.M. Baker, Y. Lin, J.A. Burdick, C.S. Chen and V.B. Shenoy. 2017. Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices. Proceedings of the National Academy of Sciences USA. 114: E4549-E4555.

L. Yang, Z. Gong, Y. Lin*, V. Chinthapenta, Q. Li, T.J. Webster and B.W. Sheldon. 2017. Disordered Topography Mediates Filopodial Extension and Morphology of Cells on Stiff Materials. Advanced Functional Materials. 1702689.

C. Fang, T.H. Hui, X. Wei, X. Shao and Y. Lin*. 2017. A combined experimental and theoretical investigation on cellular blebbing. Scientific Reports. 7: 16666.

B. Chong, Z. Gong and Y. Lin*. 2017. Modeling the adhesive contact between cells and a wavy extracellular matrix mediated by receptor-ligand interactions. Journal of Applied Mechanics. 84: 011010.

J. Qian, J. Lin, G.-K. Xu, Y. Lin* and H. Gao. 2017. Thermally assisted peeling of an elastic strip in adhesion with a substrate via molecular bonds. Journal of the Mechanics and Physics of Solids. 101: 197-208.

Before 2017

Q. Zhu, F. Zhang, A.P. Liu, J. Qian, C. Fu and Y. Lin*. 2016. Shape transformation of the nuclear envelope during closed mitosis. Biophysical Journal. 111: 2309-2316 (Featured article).

T.H. Hui, K.W. Kwan, T.T.C. Yip, H.W. Fong, K.C. Ngan, M. Yu, S. Yao, A.H.W. Ngan and Y. Lin*. 2016. Regulating the membrane transport activity and death of leukemia and epithelial cancer cells via electro-osmotic manipulation. Biophysical Journal. 110: 2769-2778.

T.H. Hui, Z.L. Zhou, J. Qian, Y. Lin*, A.H.W. Ngan and H. Gao. 2014. Volumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport. Physical Review Letters. 113: 118101.

Y. Lin*, X. Wei, J. Qian, K.Y. Sze and V.B. Shenoy. 2014. A combined finite element-Langevin dynamics (FEM-LD) approach for analyzing the mechanical response of bio-polymer networks. Journal of the Mechanics and Physics of Solids. 62: 2-18.

W. Zhang, Y. Lin, J. Qian, W. Chen and H. Gao. 2013. Tuning Molecular Adhesion via Material Anisotropy. Advanced Functional Materials. 23: 4729-4738.

K.Y. Ng, Y. Lin* and A.H.W. Ngan. 2011. Compression of Micron-sized Pillars of Anodic Aluminium Oxide Nano-honeycomb.  Journal of the Mechanics and Physics of Solids. 59: 251-264.

Y. Lin*, V.B. Shenoy, B. Hu and L. Bai. 2010. A Microscopic Formulation for the Actin-Driven Motion of Listeria in Curved Paths. Biophysical Journal. 99: 1043-1052.

Y. Lin. 2009. Mechanics model for actin-based motility. Physical Review E. 79: 021916.

K.Y. Ng, Y. Lin and A.H.W. Ngan. 2009. Deformation of anodic aluminum oxide nano-honeycombs during nanoindentation. Acta Materialia. 57: 2710-2720.

Y. Lin, M. Inamdar and L.B. Freund. 2008. The competition between Brownian motion and adhesion in soft materials.  Journal of the Mechanics and Physics of Solids. 56: 241-250.

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